Metabolic engineering of an industrial Aspergillus niger strain for itaconic acid production
نویسندگان
چکیده
منابع مشابه
Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain
BACKGROUND Itaconic acid, which has been declared to be one of the most promising and flexible building blocks, is currently used as monomer or co-monomer in the polymer industry, and produced commercially by Aspergillus terreus. However, the production level of itaconic acid hasn't been improved in the past 40 years, and mutagenesis is still the main strategy to improve itaconate productivity....
متن کاملEnhanced itaconic acid production in Aspergillus niger using genetic modification and medium optimization
BACKGROUND Aspergillus niger was selected as a host for producing itaconic acid due to its versatile and tolerant character in various growth environments, and its extremely high capacity of accumulating the precursor of itaconic acid: citric acid. Expressing the CAD gene from Aspergillus terreus opened the metabolic pathway towards itaconic acid in A. niger. In order to increase the production...
متن کاملRewiring a secondary metabolite pathway towards itaconic acid production in Aspergillus niger
BACKGROUND The industrially relevant filamentous fungus Aspergillus niger is widely used in industry for its secretion capabilities of enzymes and organic acids. Biotechnologically produced organic acids promise to be an attractive alternative for the chemical industry to replace petrochemicals. Itaconic acid (IA) has been identified as one of the top twelve building block chemicals which have ...
متن کاملExpression of the Aspergillus terreus itaconic acid biosynthesis cluster in Aspergillus niger
BACKGROUND Aspergillus terreus is a natural producer of itaconic acid and is currently used to produce itaconic acid on an industrial scale. The metabolic process for itaconic acid biosynthesis is very similar to the production of citric acid in Aspergillus niger. However, a key enzyme in A. niger, cis-aconitate decarboxylase, is missing. The introduction of the A. terreus cadA gene in A. niger...
متن کاملRelationship between morphology and itaconic acid production by Aspergillus terreus.
The morphology of filamentous fungi closely correlates with the productivity in submerged culture. Using itaconic acid (IA) production by Aspergillus terreus as a research model, the quantitative relationship between the growth form of A. terreus and IA production was investigated. IA fermentation was scaled up from shake flasks to a 7 L stirred tank bioreactor based on the quantitative relatio...
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ژورنال
عنوان ژورنال: 3 Biotech
سال: 2020
ISSN: 2190-572X,2190-5738
DOI: 10.1007/s13205-020-2080-2